Challenges of cART

U.S. economic impacts for lifetime HIV management are estimated at half a million dollars for an average 27 years’ survival (Simpson et al, 2013).




HIV drugs are a Daily Requirement.
Near-perfect (>95%) drug adherence practices are necessary to achieve and maintain viral suppression. Adherence is difficult for most patients.



The HIV-1 virus mutates at a rapid rate.  Selective pressure of ART drugs results in the need to change therapies as resistance develops.