Feline Immunodeficiency Virus (FIV)

Our ongoing studies indicate that Jericho’s small molecule can provide a significant sustained reduction of FIV virus levels in chronically-infected cats for at least 9 months in the absence of continuing treatment. Extensive testing also indicates that the drug has a good safety profile. Reducing FIV viral loads helps protect damage to cats’ immune systems.

  • As with HIV, FIV infects immune cells of of the cat. While the virus may not cause immediate symptoms, the cat’s immune system will weaken over time.
  • Approximately 4% of cats in the United States are infected with FIV and up to 23% in other countries (ME Westman et al. 2022). FIV is typically spread through bites (unlike HIV), so it is especially prevalent among aggressive male cats that live outdoors.
  • While vaccines for FIV can help reduce the frequency of infections, FDA-approved antiretroviral drugs for cats that become infected are very limited and require continuous dosing.

Symptoms of FIV may include:

  • Recurrent illnesses
  • Poor coat condition
  • Persistent fever
  • Loss of appetite
  • Swollen lymph nodes
  • Inflammation of the gums and mouth
  • Chronic infection of the eyes, skin, bladder, or lungs
  • Persistent diarrhea
  • Progressive weight loss